The overarching goal of the MATRICS proposal is to test the key hypothesis that different aggression phenotypes result from differential impairment of arousal mechanisms which in turn dysregulates three basic neural functions: regulation of control mechanisms of aggression, emotional value rating of others, and empathy and moral decision making.

Thus, we propose to deconstruct current classifications of aggression phenotypes into these three neural systems that are coupled with hypo- and hyper-arousal mechanisms.

To study these functions, we employ the same psychological tasks in both animal aggression models and human disruptive behavior disorders samples concurrent with the assessment of neural, neurochemical, genetic, autonomic nervous system and endocrinologic markers.