Disruptive Behavior Disorder (DBD), including Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) is a paediatric condition characterized by severe aggression and/or persistent defiant behavior. DBD is heterogeneous because type and severity of symptoms, outcome and associated disorders can be very different from one child to another.

Some children/adolescents meeting criteria for DBD have symptoms such as temper tantrums and reactive aggression, some may have poor empathy or pervasive rule-breaking behavior. Our understanding of the neurobiology to subtype aggression is limited.

MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within DBD and of the broader cross-disorder trait of aggression. MATRICS has assembled a strong multidisciplinary team of preclinical and clinical top researchers, both from academia and SMEs. MATRICS builds on existing fruitful EU collaborations which maximize feasibility and successful output.