University of Exeter Medical School
RILD Building, Level 4
Royal Devon & Exeter Hospital
Exeter. EX2 5DW,
The University of Exeter will lead the epigenetic analyses in MATRICS. Our main tasks within the project will be to assess genome-wide patterns of DNA methylation using cutting-edge technology and bioinformatics pipelines in human clinical CD samples, and replicate specific differentially methylated regions (DMRs) nominated by these genome-wide analyses in additional sample cohorts. We will also assess patterns of DNA methylation in top-ranked animal models of CD and IPSCs generated as part of MATRICS. We will play a leading role in the integrated analysis of genetic, epigenetic, and transcriptomic data to identify potential druggable genomic, epigenomic, transcriptomic and microRNA targets for further studies in animal models and IPSC development.